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desvenlafaxine will increase the degree or outcome of codeine by impacting hepatic enzyme CYP2D6 metabolism. Use Warning/Keep an eye on. Desvenlafaxine inhibits CYP2D6; with higher desvenlafaxine doses (ie, 400 mg) lower the CYP2D6 substrate dose by approximately fifty%; no dosage adjustment required with desvenlafaxine doses 7 consecutive days pro